李霞

2018年10月01日 11:40 admin 点击:[]

 

李霞 简历

教授/博士生导师

主要从事基于分子靶点海洋天然药物、先导物的发现及作用机制的研究。2005年博士毕业于沈阳药科大学。2007年11月-2010年7月在山东大学天然产物化学生物学教育部国家重点实验室从事博士后工作。2004年5月至2005年5月、2013年3月至2014年4月在日本富山医科药科大学复方药理分野、美国印第安纳大学医学院药理毒理系从事药物药理毒理学研究。

xiali@sdu.edu.cn

1近5年代表科研论文(*通讯作者)

1. Xia Li, Hongguang Ma, Lin Li, Yifan Chen, Xiao Sun, Zizheng Dong, Jing-Yuan Liu, Weiming Zhu & Jian-Ting Zhang. Novel synthetic bisindolylmaleimide alkaloids inhibit STAT3 activation by binding to the SH2 domain and suppress breast xenograft tumor growth Oncogene 37, pages2469–2480 (2018,IF 7.93)

2. Wang QL, Guo C, Qi J, Ma JH, Liu FY, Lin SQ, Zhang CY, Xie WD, Zhuang JJ, Li Xia*. Protective effects of 3β-angeloyloxy-8β, 10β-dihydroxyeremophila-7(11)-en-12, 8α-lactone onparaquat-induced oxidative injury in SH-SY5Y cells. J Asian Nat Prod Res. Jan 21:1-13. (2018)

3. Sun Xiao, Li Lin, Ma Hongguang, Sun Pu, Wang Qilin, Zhang Tingting, Shen Yuemao, Zhu Wei-Ming*,Li Xia*, 2017. BMA-155Cl induces autophagy and apoptosis associated with the NF-κB p65 pathway in HepG-2 cells in vitro and in vivo. Acta Pharmacol Sin. 38(4),524~38.(IF3.23)

4. Li Ke , Wang Feng, Cao Wenbin, Lv Xiaoxi, Hua Fang, Cui Bing,Yu Jiaojiao, Zhang Xiaowei, Shang Shuang, Liu Shanshan, Yu Jinmei, Han Mingzhe, Huang Bo, Zhang Tingting, Li Xia, Jiang Jiandong, Hu Zhuowei(*) TRIB3 Promotes APL Progression through Stabilization of the Oncoprotein PML-RARα and Inhibition of p53-Mediated Senescence, Cancer Cell, 2017.05.08, 31(5):697~710(IF: 27.11)

5. Zhao Xinxin, Chang Juanjuan, Wang Qinlin, Lu Rong, Li Lingjun, Sun Xiao, Xie Weidong, Li Xia*.5,6-Dihydroxy-3,7,4'-trimethoxyflavonol induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma cells. J Asian Nat Prod Res. 2016 18(11):1079-90.

6. Liu Guoliang, Qian Jiahui, Hua Jing, Cai Feng,Li Xia*, Liu Lei. An economical synthesis of substituted quinoline-2-carboxylates through the potassium persulfate-mediated cross-dehydrogenative coupling of N-aryl glycine derivatives with olefins. Org Biomol Chem. 2016 Jan 21;14(3):1147-52. (SCI:3.65).

7. Sun Xiao, Jiang Changyou, Ma Lisha, Zhao Xin, Chang Juanjuan, Zheng Beibei, Li Lin, Xie Weidong, Li Xia*. 3β-Angeloyloxy-8β,10β-dihydroxyeremophila-7(11)-en-12,8α-lactone Inhibits Lipopolysaccharide-Induced Nitric Oxide Production in RAW264.7 Cells. Biol Pharm Bull. 2015;38(6):836-43. (SCI:1.88).

8. Lu Rong, Liu Shan,Wang Qilin, Li Xia*.Nanoemulsions as novel oral carriers of stiripentol: insights into the protective effect and absorption enhancement. Int J Nanomedicine. 2015 31;10:4937-46. (SCI:4.38).

9. Lu Rong, Liu Shan,Wang Qilin, Li Xia*. Enhanced bioavailability of raloxifene hydrochloride via dry suspensions prepared from drug/HP-β-cyclodextrin inclusion complexes. Pharmazie. 2015 70(12):791-7 (SCI:1.1).

10.Fu Peng, Kong Fan-Dong, Li Xia, Wang Yi, Zhu Wei-Ming, (*)Cyanogramide with a new spiro[indolinone-pyrroloimidazole] skeleton from Actinoalloteichus cyanogriseus., Org Lett., 2014.7.18, 16(14) :3708~3711

11. Li Lin, Zheng Bei-Bei, Ma Li-Sha, Sun Xiao, Chang Juan-Juan, Xie Wei-Dong, Li Xia*. Telekin suppresses human hepatocellular carcinoma cells in vitro by inducing G2/M phase arrest via the p38 MAPK signaling pathway.Acta Pharmacol Sin.35(10), 1311-1322. 2014.(SCI:2.50)

12. Liu Shan-Shan,Wu Di, Li Lin, Sun Xiao, Xie Wei-Dong,Li Xia*.NF-κB activation was involved in reactive oxygen species-mediated apoptosis and autophagy in 1-oxoeudesm-11(13)-eno-12,8α-lactone-treated human lung cancer cells. Arch Pharm Res. 37(8),1039-1052. 2014

13.Liu Shan-Shan,Wang Yan-Feng,Ma Li-Sha, Zheng Bei-Bei, Li Lin, Xie Wei-Dong,Li Xia*. 1-Oxoeudesm-11(13)-eno-12,8a-lactone induces G(2)/M arrest and apoptosis of human glioblastoma cells in vitro.Acta Pharmacol Sin.34(2),271-281.2013. (SCI:2.50).

14.Zheng Bei-Bei, Wu Le-Hao, Ma Li-Sha, Liu Shan-Shan,Li Lin, Xie Wei-Dong, Li Xia*. Telekin induces apoptosis associated with the mitochondria-mediated pathway in human hepatocellular carcinoma Cells. Biological & Pharmaceutical Bulletin 36(7), 1118-1125. 2013.

15.Ma Li-Sha#, Jiang Chang-You#, Cui Min, Lu Rong, Liu Shan-Shan, ZhengBei-Bei,Li Lin, Xie Wei-Dong, Li Xia*. Fluopsin C induces oncosis of human breast adenocarcinoma cells. Acta Pharmacol Sin. 34(8),1093-1100. 2013. (SCI:2.50)

16.Xie Wei-Dong*, Li Xia*, Zhao Jiang-He, Liu Yong-Heng, Row Kyung-Ho. Abietane diterpenoids from Isodon inflexus. Phytochemistry 81(1), 153-158. 2012. (SCI:3.4)

17.Li Xia, Wu William K.K., Sun Bin, Cui Min, Liu Shan-Shan, Gao Jian, Lou Hong-Xiang*. Dihydroptychantol A, a macrocyclic bisbibenzyl derivative, induces autophagy and following apoptosis associated with p53 pathway in human osteosarcoma U2OS cells. Toxicol Appl Pharmacol.251(2), 146-154. 2011. (SCI: 4.45)

18. Li Xia, Zhao Ying, Wu William K. K., Liu Shan-Shan, Cui Min, Lou Hong-Xiang*. Solamargine induces apoptosis associated with p53 transcription-dependent and transcription-independent pathways in human osteosarcoma U2OS cells. Life Sci. 88(7-8), 314-321.2011. (SCI:2.57)

19.Li Xia, Zhao Ying, Ji Mei, Liu Shan-Shan, Cui Min, Lou Hong-Xiang*. Induction of actin disruption and downregulation of P-glycoprotein expression by Solamargine in multidrug-resistant K562/A02 cells. Chin Med J.(Engl)124(13), 2038-2044. 2011. (SCI: 0.9)

20. Cui Min; Zhang Ya-Hong, Liu Shan-Shan, Xie Wei-Dong,Ji Mei, Lou Hong-Xiang,Li, Xia.*1-oxoeudesm-11(13)-ene-12,8α-lactone-induced apoptosis via ROS generation and mitochondria activation in MCF-7 cells. Archives of Pharmacal Research 34(8), 1323-1329. 2011. (SCI: 1.6)

21.Fu Peng, Liu Pei-Pei,Li Xia, Wang Yi, Wang Shu-Xia, Hong Kui, Zhu Wei-Ming*.Cyclic Bipyridine Glycosides from the Marine-Derived Actinomycete Actinoalloteichus cyanogriseus WH1-2216-6. Org Lett. 13(22),5948-51. 2011. (SCI:5.86)

2奖励:

1.李霞,娄红祥,孙斌,谢卫东。基于P-gp靶点双联苄化合物逆转肿瘤多药耐药实验研究。山东省教育厅,山东省高等学校优秀科研成果三等奖, 2010年12月。

2.李霞 娄红祥谢卫东 基于溶酶体靶点龙葵碱抗肿瘤多药耐药作用机制的研究。山东省教育厅,山东高等学校优秀科研成果三等奖 2012年12月。

3.李霞,谢卫东.天然小分子化合物抗肿瘤作用及其机制的研究。威海市科协,威海市自然科学优秀学术成果奖二等奖, 2013年 12月。

3.主持或参加科研项目:

1.教育部“ 天然产物化学生物学” 创新团队IRT_17R68, 2018.01–2020.12, 300万元 参与

2、国家自然科学基金面上项目,81273532、基于微管靶点新结构双吲哚马来酰亚胺HD-ZWM288抗肿瘤作用及其机制的研究、2013/01-2016/12,主持。

3、国家自然科学基金面上项目,81072660、基于溶酶体靶点龙葵碱抗肿瘤细胞多药耐药作用及其机制的研究、2011/01-2013/12,主持。


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