陈晓

2022年11月01日 19:50  点击:[]


陈晓 博士

山东大学齐鲁青年学者研究员

工作地点:山东大学(威海)海洋学院 628

电子邮箱:xc@sdu.edu.cn

工作经历

2022/01 至今 齐鲁青年学者研究员·山东大学·海洋学院

2021/04 - 2021/09 副研究科学家(Associate Research Scientist·美国哥伦比亚大学医学中心·遗传发育系

2018/04 - 2021/04 博士后研究员·美国哥伦比亚大学医学中心·遗传发育系


教育经历

2016/10 - 2017/09 国家公派联合培养博士·美国密歇根大学·医学院

2012/09 - 2018/01 水生生物学博士·中国海洋大学·海洋生物多样性与进化研究所

2008/09 - 2012/07 理学学士·中国海洋大学·生命科学系


研究方向

真核生物基因表达的表观遗传调控机制

§ 细胞外环境因素改变相关的基因表达调控

§ 细胞内染色质属性改变相关的基因表达调控


主持项目

2023/01 - 2026/12 国家自然科学基金面上项目:以纤毛虫为材料:单细胞真核生物适应低氧环境的表观遗传调控机制探讨

2022/07 - 2025/06 江苏省自然科学基金青年科学基金项目:以人工染色体为材料:低氧对组蛋白乙酰化修饰的影响

2022/01 - 2027/01 山东大学齐鲁青年学者人才项目


获奖荣誉

2021 山东大学齐鲁青年学者

2019 山东省优秀博士毕业论文

2017 国际原生动物学会“Holz-Conner”


教学贡献

2022/09 至今 教授山东大学海洋学院研究生课程专业外语(博士)


学术职务

2022/06 - 至今 SCI期刊Frontiers in Genetics专辑Biomedical Application of DNA Modifications特邀编辑

2020/04 - 至今 SCI期刊Frontiers in Marine Science客座编辑


学会成员

2019/05 - 2021/09 纽约科学院(New York Academy of Sciences)成员

2017/07 至今 国际原生动物学会(International Society of Protistologists)成员


学术会议

2021/07 International Society of Protistologists online meeting. 大会报告

2020/09 Epigenetics & Chromatin Meeting, Cold Spring Harbor, USA, 墙报展示

2017/11 International Symposium on Biodiversity and Evolution of Protozoa, Guangzhou, China, 大会报告


发表论文

发表 SCI 文章 30 余篇,累计引用 900 余次。核心成果发表在 PNASNucleic Acids ResearchProtein & CellMolecular Ecology Resources 等主流期刊上,累计影响因子 500 余点(平均单篇影响因子 14.9)。


代表性工作

1. Kartik N. Rajagopalan, Xiao Chen (co-first author), Daniel N. Weinberg, Haifen Chen, Jacek Majewski, C. David Allis & Chao Lu (2021). Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation. PNAS, 118(9), e2021795118. DOI: 10.1073/pnas.2021795118.

2. Xiao Chen, Yaohan Jiang, Feng Gao, Weibo Zheng, Timothy J. Krock, Naomi A. Stover, Chao Lu, Laura A. Katz & Weibo Song (2019). Genome analyses of the new model protist Euplotes vannus focusing on genome rearrangement and resistance to environmental stressors. Molecular Ecology Resources, 19(5), 1292-1308. DOI: 10.1111/1755-0998.13023.

3. Yuanyuan Wang, Xiao Chen (co-first author), Yalan Sheng, Yifan Liu & Shan Gao (2017). N6-adenine DNA methylation is associated with H2A.Z-containing well-positioned nucleosomes in Pol II-transcribed genes in Tetrahymena. Nucleic Acids Research, 45(20), 11594-11606. DOI: 10.1093/nar/gkx883.

4. Xiao Chen, Shan Gao, Yifan Liu, Yuanyuan Wang, Yurui Wang & Weibo Song (2016). Enzymatic and chemical mapping of nucleosome distribution in purified micro- and macronuclei of the ciliated model organism, Tetrahymena thermophila. Science China Life Sciences, 59(9), 909-919. DOI: 10.1007/s11427-016-5102-x.

5. Xiao Chen, Xiaolu Zhao, Xiaohui Liu, Alan Warren, Fangqing Zhao & Miao Miao (2015). Phylogenomics of non-model ciliates based on transcriptomic analyses. Protein & Cell, 6(5), 373-385. DOI: 10.1007/s13238-015-0147-3.

6. Yinglu Li, Elizabeth M. Goldberg, Xiao Chen (co-first author), Xinjing Xu, John T. McGuire, Giuseppe Leuzzi, Dimitris Karagiannis, Tiffany Tate, Nargess Farhangdoost, Cynthia Horth, Esther Dai, Zhiming Li, Zhiguo Zhang, Benjamin Izar, Jianwen Que, Alberto Ciccia, Jacek Majewski, Angela J. Yoon, Laurie Ailles, Cathy Lee Mendelsohn & Chao Lu (2022). Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas. Molecular Cell, 82(20), 3901-3918. DOI: 10.1016/j.molcel.2022.09.007.

7. Yinglu Li, Xiao Chen (co-first author) & Chao Lu (2021). The interplay between DNA and histone methylation: molecular mechanisms and disease implications. EMBO Reports, e51803. DOI: 10.15252/embr.202051803.

8. Xiao Chen, Yurui Wang, Yalan Sheng, Alan Warren & Shan Gao (2018). GPSit: an automated method for evolutionary analysis of nonculturable ciliated microeukaryotes. Molecular Ecology Resources, 18(3), 700-713. DOI: 10.1111/1755-0998.12750.

9. Weibo Zheng, Huan Dou, Chao Li, Saleh A. Al-Farraj, Adam Byerly, Naomi A. Stover, Weibo Song, Xiao Chen (corresponding author) & Lifang Li (2022). Comparative genome analysis reveals cis-regulatory elements on gene-sized chromosomes of ciliated protists. Frontiers in Microbiology, 13, 775646. DOI: 10.3389/fmicb.2022.775646.

10. Xiao Chen, Chundi Wang, Bo Pan, Borong Lu, Chao Li, Zhuo Shen, Alan Warren & Lifang Li (2020). Single-cell genomic sequencing of three peritrichs (Protista, Ciliophora) reveals less biased stop codon usage and more prevalent programmed ribosomal frameshifting than in other ciliates. Frontiers in Marine Science, 7, 602323. DOI: 10.3389/fmars.2020.602323.






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