康元环

2021年09月14日 14:58  点击:[]


姓名:康元环

邮箱:kangyuanhuan@sdu.edu.cn

科研方向:

1)海洋生物病原菌致病机制研究

2)海洋生物微生态制剂研制及应用

3)噬菌体靶向防治海洋生物病害技术的开发及应用

主持和参加的主要科研项目:

1)吉林省科技厅自然科学基金,丝氨酸/苏氨酸蛋白激酶YihE介导磷酸化修饰调控维氏气单胞菌毒力的分子机制,2021/01-2023/12,主持。

2)吉林省教育厅十三五科学技术项目,维氏气单胞菌型分泌系统核心基因ascA/ascB功能研究,2019/01-2020/12,主持。

3农业农村部淡水渔业健康养殖重点实验室开放课题,以CTB为分子佐剂表面展示拟态弧菌外膜蛋白OmpU新功能型干酶乳杆菌的构建及免疫保护效果研究2020/01-2022/12,主持。

4)吉林农业大学博士启动基金,表面展示维氏气单胞菌保护性抗原重组乳酸菌的构建及免疫效果评价,2018/10-2020/12,主持。

5)国家自然科学基金,基于SOS调控通路牛荚膜A型多杀性巴氏杆菌耐药抑制剂靶标的筛选,2018/01- 2020/12,主要参加人。

6)吉林省科技厅自然科学基金,基于差异蛋白质组学的维氏气单胞菌生物被膜形成相关蛋白的筛选及其功能研究,2017/01- 2019/12,主要参加人。

7)吉林省科技厅科技支撑计划,牛羊布氏杆菌病防控技术研究及产品研发,2016/01- 2018/12,主要参加人。

8)吉林省科技厅科技支撑计划,维氏气单胞菌主要保护性抗原基因重组乳酸菌关键技术研究,2015/01- 2017/12,主要参加人。

主要科研成果:

1)淡水鱼抗病营养及综合防控技术创新与应用,吉林省科学技术协会,科技进步奖,二等奖,2019.10.23

2)吉林省框镜鲤源维氏气单胞菌相关毒力基因的研究,吉林省科学技术协会,自然科学奖,三等奖,2013.10.31

部分代表性SCI文章:

(1) Bin-Tong Yang, Yu-Feng Sun, Li-Nan Cao, Sayed Haidar Abbas Raza, Jin-Hua Zhou, Ya-Nan Li, Wu-Wen Sun, Gui-Qin Wang, Xiao-Feng Shan, Yuan-Huan Kang*, Ai-Dong Qian*. Comparative proteomic analysis reveals novel potential virulence factors of Aeromonas veronii. Annals of the New York Academy of Sciences. 2021, 1486 (1): 58-75.

(2) Bin-Tong Yang, Hai-Chao Song, Ding-Jie An, Dong-Xing Zhang, Sayed Haidar Abbas Raza, Gui-Qin Wang, Xiao-Feng Shan, Ai-Dong Qian, Yuan-Huan Kang*, Chun-Feng Wang*. Functional Analysis of preA in Aeromonas veronii TH0426 Reveals a Key Role in the Regulation of Virulence and Resistance to Oxidative Stress. International Journal of Molecular Sciences, 2020, 21 (1): 98.

(3) Ying Li, Bin-Tong Yang, Jia-Xin Tian, Wu-Wen Sun, Gui-Qin Wang, Ai-Dong Qian, Xiao-Feng Shan*, Yuan-Huan Kang*. An iTRAQ-Based Comparative Proteomics Analysis of the Biofilm and Planktonic States of Aeromonas veronii TH0426. International Journal of Molecular Sciences, 2020, 21 (4): 1450.

(4) Tong Li, Sayed Haidar Abbas Raza, Bin-Tong Yang, Yu-Feng Sun, Gui-Qin Wang, Wu-Wen Sun, Ai-Dong Qian, Chun-Feng Wang, Yuan-Huan Kang*, Xiao-Feng Shan*. Aeromonas veronii Infection in Commercial Freshwater Fish: A Potential Threat to Public Health. Animals, 2020, 10 (4): 608.

(5) Bin-Tong Yang, Chong Chen, Yu-Feng Sun, Li-Nan Cao, Dong-Xing Zhang, Wu-Wen Sun, Lei Zhang, Gui-Qin Wang, Xiao-Feng Shan, Yuan-Huan Kang*, Ai-Dong Qian*. Comparative genomic analysis of different virulence strains reveals reasons for the increased virulence of Aeromonas veronii. Journal of Fish Diseases, 2021, 44 (1): 11-24.

(6) Bin-Tong Yang, Dong-Xing Zhang, Tong-Lei Wu, Zhi-Qiang Zhang, Sayed Haidar Abbas Raza, Nicola Schreurs, Lei Zhang, Gui-Lian Yang, Chun-Feng Wang, Ai-Dong Qian, Yuan-Huan Kang*, Xiao-Feng Shan*. Maltoporin (LamB protein) contributes to the virulence and adhesion of Aeromonas veronii TH0426. Journal of Fish Diseases, 2019, 42 (3) :379–389.

(7) Yuan-Huan Kang, Xiao-Yi Pan, Yang Xu, Shahrood Ahmed Siddiqui, Chun-Feng Wang, Xiao-Feng Shan*, Ai-Dong Qian*. Complete genome sequence of the fish pathogen Aeromonas veronii TH0426 with potential application in biosynthesis of pullulanase and chitinase. Journal of Biotechnology, 2016, 227:81-82.

(8) Yuan-Huan Kang(#), Wei Cong(#), Si-Yuan Qin, Xiao-Feng Shan*, Yun-Hang Gao, Chun-Feng Wang, Ai-Dong Qian*. First report of Toxoplasma gondii, Dirofilaria immitis, and Chlamydia felis infection in stray and companion cats in Northeastern and Eastern China. Vector Borne & Zoonotic Diseases, 2016, 16 (10) : 654-658.

(9) Chong Chen, Bin-Tong Yang, Sayed Haidar Abbas Raza, Dong-Xing Zhang, Tong-Lei Wu, Zhi-Qiang Zhang, Irfan Ullah, Rajwali Khan, Gui-Lian Yang, Chun-Feng Wang, Gui-Qin Wang, Xiao-Feng Shan, Yuan-Huan Kang*, Ai-Dong Qian*. Role of Myeloperoxidase of northern snakehead (Channa argus) in Aeromonas veronii infection. Microbial Pathogenesis, 2019, 135: 103622.

(10) Song Hai-Chao, Yang Bin-Tong, Zhao Tong, Sun Yu-Feng, Zhou Jin-Hua, Shan Xiao-Feng, Qian Ai-Dong, Sun Wen-Chao*, Kang Yuan-Huan*. Comparative genomics analysis of strains from diverse sources reveals the evolutionary relationship of Aeromonas veronii. Microbial Pathogenesis, 2021, 159: 105134.

(11) Yuan-Huan Kang(#), Wei Cong(#), Xiang-Yan Zhang, Chun-Feng Wang, Xiao-Feng Shan, Ai-Dong Qian*. Hepatitis E virus seroprevalence among farmers, veterinarians and control subjects in Jilin province, Shandong province and Inner Mongolia Autonomous Region, China. Journal of Medical Virology, 2017, 89 (5) : 872-877.

(12) Hai-Peng Zhang(#), Yuan-Huan Kang(#), Ling-Cong Kong, An-Qi Ju, Yi-Ming Wang, Inam Muhammad, Dong-Xing Zhang, Ai-Dong Qian, Xiao-Feng Shan*, Hong-Xia Ma*. Functional analysis of hisJ in Aeromonas veronii reveals a key role in virulence. Annals of the New York Academy of Sciences, 2020, 1465 (1) : 146-160.

(13) Dong-Xing Zhang(#), Yuan-Huan Kang(#), Sheng Zhan, Ze-Lin Zhao, Sheng-Nan Jin, Chong Chen, Lei Zhang, Jin-Yu Shen, Chun-Feng Wang, Gui-Qin Wang, Xiao-Feng Shan*, Ai-Dong Qian*. Effect of Bacillus velezensis on Aeromonas veronii-induced intestinal mucosal barrier function damage and inflammation in Crucian carp (Carassius auratus). Frontiers in Microbiology, 2019, 10: 2663.

(14) Dong-Xing Zhang(#), Yuan-Huan Kang(#), Long Chen , Shahrood Ahmed Siddiqui, Chun-Feng Wang, Ai-Dong Qian*, Xiao-Feng Shan*. Oral immunization with recombinant Lactobacillus casei expressing OmpAI confers protection against Aeromonas veronii challenge in common carp, Cyprinus carpio. Fish & Shellfish Immunology, 2018, 72 : 552-563.

(15) Ming-Fang Song(#), Yuan-Huan Kang(#), Dong-Xing Zhang, Long Chen, Jian-Fei Bi, Hai-Peng Zhang, Lei Zhang, Ai-Dong Qian*, Xiao-Feng Shan*. Immunogenicity of extracellular products from an inactivated vaccine against Aeromonas veronii TH0426 in koi, Cyprinus carpio. Fish & Shellfish Immunology, 2018, 81: 176-181.

(16) Yi-Di Kong(#), Yuan-Huan Kang(#), Jia-Xin Tian, Dong-Xing Zhang, Lei Zhang, Luo-Tao Tao, Tong-Lei Wu, Ying Li, Gui-Qin Wang*, Xiao-Feng Shan*. Oral immunization with recombinant Lactobacillus casei expressing flaB confers protection against Aeromonas veronii challenge in common carp, Cyprinus carpio. Fish & Shellfish Immunology, 2019, 87 : 627-637.

(17) Hai-Chao Song(#), Yuan-Huan Kang(#), Ai-Dong Qian, Xiao-Feng Shan, Ying Li, Lei Zhang, Hai-Peng Zhang, Wu-Wen Sun*. Inactivation of the T6SS inner membrane protein DotU results in severe attenuation and decreased pathogenicity of Aeromonas veronii TH0426. BMC Microbiology, 2020, 20 (1) : 76.

(18) Hai-Chao Song(#), Yuan-Huan Kang(#), Dong-Xing Zhang, Long Chen, Ai-Dong Qian, Xiao-Feng Shan*, Ying Li*. Great effect of porin (aha) in bacterial adhesion and virulence regulation in Aeromonas veronii. Microbial pathogenesis, 2019, 126: 269-278.

(19) Dong-Xing Zhang(#), Yuan-Huan Kang(#), Ming-Fang Song, Hui-Ping Shu, Song-Ning Guo, Jun-Peng Jia, Luo-Tao Tao, Ze-Lin Zhao, Lei Zhang, Chun-Feng Wang, Gui-Qin Wang, Ai-Dong Qian*, Xiao-Feng Shan*. Identity and virulence properties of Aeromonas isolates from healthy Northern snakehead (Channa argus) in China. Letters in Applied Microbiology, 2019, 69 (2) : 100-109.

(20) Luo-Tao Tao(#), Yuan-Huan Kang(#), Lei Zhang, Qiu-Mei Shi, Ying Li, Tong-Lei Wu, Ai-Dong Qian, Wu-Wen Sun*, Xiao-Feng Shan*. Cadaverine reverse transporter (CadB protein) contributes to the virulence of Aeromonas veronii TH0426. International Microbiology, 2020, 23 : 489-499.

部分代表性中文文章:

(1) 康元环, 杨滨僮, 单晓枫, 钱爱东. 细菌基因敲除策略及其在维氏气单胞菌研究中的应用. 中国生物制品学杂志, 2019, 04:1-4.

(2) 康元环, 张冬星, 杨滨僮, 张贺亮, 孙武文, 单晓枫, 钱爱东. 维氏气单胞菌最新研究进展.中国人兽共患病学报, 2018, 34(05): 452-459.

(3) 康元环, 陈亨利, 张冬星, 张海月, 安鼎杰, 田佳鑫, 贾俊鹏, 孙武文, 单晓枫, 钱爱东.维氏气单胞菌TH0426株外膜蛋白lamB基因的原核表达及其免疫原性分析.中国兽医学报, 2017,37(12):2333-2338.

(4) 康元环, 孟庆峰, 夏京津, 龙继兵, 盛宇轩, 陈龙, 单晓枫, 钱爱东.乌鳢致病性维氏气单胞菌的分离鉴定及生物学特性研究.动物医学进展, 2014, 35(05):40-43.

(5) 康元环, 杨滨僮, 孟庆峰, 陈龙, 单晓枫, 王惠, 钱爱东.不同宿主来源的维氏气单胞菌外膜蛋白AⅡ基因的克隆及比较.中国兽医科学, 2014, 44(03):271-276.

(6) 康元环, 王庆奎, 比尔来西肯·赛都力, 边宇, 单晓枫, 吴同垒, 钱爱东.应用IVIAT对动物病原菌体内诱导抗原的筛选研究进展.中国预防兽医学报, 2013, 35(11): 943-945.

获奖情况:

吉林省优秀博士学位论文

吉林省优秀硕士学位论文

 


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