硕士生导师

姓名：厉萍

职称：副研究员

邮箱:liping2018@email.sdu.edu.cn

专业领域：海洋科学、资源与环境

研究方向：环境生物学、分子生物学、蛋白组学、低温冷冻生物学

讲授课程：分子生物学、基因工程、分子育种学、海洋生物制品学

主要致力于河流及近海水环境污染物分布特征、典型污染物对水生生物潜在的毒性效应及分子机制、以及生态修复等研究。曾先后主持国家自然基金青年项目、捷克自然基金项目、科技部重点研发计划子任务、山东省自然基金面上项目、中央院所基本科研业务费等多项课题。先后发表学术论文90余篇，其中第一作者（或通讯作者）48篇，参编中英文专著4部，获得授权发明专利3项。

教育工作经历

• 2004年7月毕业于山东师范大学生命科学学院，获学士学位。

• 2007年7月获华中农业大学水产学院湿地资源与环境专业，获硕士学位。

• 2007年10月至2011年10月赴捷克南波西米亚大学水产养殖与水资源保护学院从事鱼类精液超低温冷冻保存技术及精子冷冻损伤机制研究，并获得博士学位；曾赴日本筑波大学下田海洋研究中心实验室访问交流（2009年1-4月）；在捷克获得由国家留学基金委颁发的2010年度国家优秀自费留学生奖学金。

• 2011年11月至2012年11月赴新加坡国立大学生物系从事博士后研究工作，主要运用代谢组学和iTRAQ标记的蛋白质组学研究水体污染物对鱼类影响的分子机制。

• 2007年7月至2018年4月任职于中国水产科学研究院长江水产研究所，2014年晋升副研究员，2015年获第三批“中国水产科学研究院百名科技英才培育计划”人选。

• 2018年5月至今 山东大学（威海），海洋学院。

主持科研项目

• 国家重点研发计划“蓝色粮仓科技创新”专项, 2018YFD0900905，“我国重要渔业水域食物网结构特征与生物资源补充机制”项目-“关键资源种群衰退与修复机理”，2018/12-2022/12，任务负责人

• 山东省自然科学基金面上项目，ZR2019MC011，喹诺酮类抗生素对鲤鱼生殖内分泌干扰作用研究，2019/01-2021/12

• 浙江省淡水水产研究所，农业部淡水渔业健康养殖重点实验室开放课题，ZJK201913，喹诺酮类抗生素对鲤鱼肝和肾胁迫效应研究，2019/01-2020/12

• Czech Science Foundation, GACR 16-02407Y, Tf in the seminal plasma of carp and some sturgeons can help us to identify the role of proteins in the freezing of sperm.2016/01-2018/12

• 国家自然基金青年项目，31402301，鲟鱼精子质量蛋白质标志物的筛选与功能研究，2015/01-2017/12

• 中央级公益性科研院所基本科研业务费优青项目，2015B02YQ01，水产生物生殖调控相关机制及技术研究-达氏鲟精原干细胞体外增殖与冷冻保存，2015/01- 2017/12

• 中国水产科学研究院“院5511人才工程百名科技英才培育计划”人选，2015年，渔业资源保护与利用学科

• Grant agency of University of South Bohemia, 003/2010/Z, Effect of cryopreservation on phosphorylation state of sperm proteins of common carp,Cyprinus carpioL, 2010/01-2010/12

• Grant agency of University of South Bohemia, 072/2008/P, Ice-age endurance: difference expressions of sperm proteins before and after cryopreservation in teleost fishes, 2009/01-2009/12

近三年代表性论文（#代表共同第一作者，*代表通讯作者）:

1. Zhang, S.Q.#, Zhao, X.L.#, He, S.W., Xing, S.Y., Cao, Z.H.,Li, P.*, Li, Z.H.*, 2022. Effects of long-term exposure of norfloxacin on the HPG and HPT axes in juvenile common carp. Environmental Science and Pollution Research, 29, 44513-44522.

2. Cao, X.Q., He, S.W., Liu, B., Wang, X., Xing, S.Y., Cao, Z.H., Chen, C.Z.,Li, P.*, Li, Z.H.*, 2022. Exposure to enrofloxacin and depuration: Endocrine disrupting effect in juvenile grass carp (Ctenopharyngodon idella), Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 257, 109358.

3. Ru, J.C., Zhao, X.L., Cao, Z.H., Chen, C.Z.,Li, P.*, Li, Z.H.*, 2022. Chronic toxic effects of polystyrene micro-plastics, DCOIT and their combination on Marine Chlorella sp. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 261, 109426.

4. Wang, X.#,Li, P.#, He, S.W., Xing, S.Y., Cao, Z.H., Liu, B., Li, Z.H.*, 2022. Effects of tralopyril on histological, biochemical and molecular impacts in Pacific oyster,Crassostrea gigas. Chemosphere, 289, 133157.

5. Chen, C.Z.#,Li, P.#, Wang, W.B.*, Li, Z.H.*, 2022. Response of growth performance, serum biochemical parameters, antioxidant capacity, and digestive enzyme activity to different feeding strategies in common carp (Cyprinus carpio) under high-temperature stress. Aquaculture, 548, 737636.

6. Cao, Z.H.#,Li, P.#, Cao, X.Q., Wang, X., Liu, B., He, S.W., Gao, G., Lu, R.*, Li, Z.H.*, 2022. Reproductive toxicity of environmental levels of triphenyltin to the marine rotifer,Brachionus plicatilis. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 254, 109272.

7. Liu, B.#,Li, P.#, He, S.W., Xing, S.Y., Cao, Z.H., Cao, X.Q., Wang, X., Li, Z.H.*, 2022. Effects of short-term exposure to tralopyril on physiological indexes and endocrine function in turbot (Scophthalmus maximus), Aquatic Toxicology, 245, 106118.

8. Chen, C.Z.#,Li, P.#, Liu, L., Li, Z.H.*, 2022. Transcriptomic and proteomic analysis of Chinese rare minnow (Gobiocypris rarus) larvae in response to acute waterborne cadmium or mercury stress. Aquatic Toxicology, 246, 106134.

9. Liu, B.#,Li, P.#, He, S.W., Xing, S.Y., Liu, L., Li, Z.H.*, 2022. Chronic exposure to Tralopyril induced abnormal growth and calcium regulation of turbot (Scophthalmus maximus), Chemosphere, 299, 134405.

10. Zhao, X.L.#,Li, P.#, Qu, C.F., Lu, R.*, Li, Z.H.*, 2022. Phytotoxicity of environmental norfloxacin concentrations on the aquatic plantSpirodela polyrrhiza: evaluation of growth parameters, photosynthetic toxicity and biochemical traits. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 258, 109365.

11. Wang, X.#,Li, P.#, Cao, X.Q., Liu, B., He, S.W., Cao, Z.H., Xing, S.Y., Liu, L., Li, Z.H.*, 2022. Effects of ocean acidification and tralopyril on bivalve biomineralization and carbon cycling: a study of the Pacific Oyster (Crassostrea gigas)   Environmental Pollution, 313, 120161.

12. Xing, S.Y.#,Li, P.#, He, S.W., Cao, Z.H., Wang X., Cao, X.Q., Liu, B., You, H., Li, Z.H.*, 2022. Physiological responses in Nile tilapia (Oreochromis niloticus) induced by combined stress of environmental salinity and triphenyltin. Marine Environmental Research, 180, 105736.

13. Li, P., Li, Z.H.*,2021. Neurotoxicity and physiological stress in brain of zebrafish chronically exposed to tributyltin. Journal of Toxicology and Environmental Health, Part A Current Issues, 84, 20-30.

14. Li Z.H.*,Li P.*,Wu Y.H., 2021. Effects of temperature fluctuation on endocrine disturbance of grass carpCtenopharyngodon idellaunder mercury chloride stress. Chemosphere. 263: 128137.

15. Li, Z.H.*,Li, P*. 2021. Effects of the tributyltin on the blood parameters, immune responses and thyroid hormone system in zebrafish.Environmental Pollution, 268, 115707.

16. Li Z.H.*,Li P.*,Wu Y.H., 2021. Regulation of glutathione-dependent antioxidant defense system of grass carpCtenopharyngodon idellaunder the combined stress of mercury and temperature. Environmental Science and Pollution Research, 28, 1689-1696.

17. Li, P., Li, Z.H.*,2020. Tributyltin induces the tissue-specific stresses in zebrafish, a study in various tissues of muscle, gill and intestine. Bulletin of Environmental Contamination and Toxicology, 105, 847–852.

18. Li P., Li Z.H.*, Wu Y.H.,2020. Interactive effects of temperature and mercury exposure on the stress-related responses in the freshwater fishCtenopharyngodon idella. Aquaculture Research,00: 1-8.DOI: 10.1111/are.15058

19. Li P.,Li Z.H.*, 2020. Toxicity evaluation of triphenyltin in zebrafish larvae by embryonic malformation, retinal development, and GH/IGF axis. Fish Physiology and Biochemistry.46, 2101-2107

20. Li P.,Li Z.H.*, 2020. Environmental co-exposure to TBT and Cd caused neurotoxicity and thyroid endocrine disruption in zebrafish, a three-generation study in a simulated environment. Environmental Pollution. 259: 113868.

21. Li P.,Li Z.H.*, Zhong L., 2020.Parental exposure to triphenyltin inhibits growth and disrupts thyroid function in zebrafish larvae.Chemosphere. 240: 124936.